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		DentalXS
Access Portal for Dental Informatics, Computerized Dentistry and Dental CAD/CAM
	BioZyram Both tissue engineering and biomaterials have made tremendous strides recently; some tissue engineered products have come to the market, and others are in development. Yet major questions remain unanswered. A fundamental issue that cell biologists could address is describing (and predicting) the cascade of biochemical and cellular reactions that occur as a function of time and implant material; surface texture; microporosity; pore size, density, and connectivity; and 3-dimensional configuration. Behavior of ceramics, a subset of tissue engineering scaffold materials and a mainstay of dental restorations, has been studied extensively for thicknesses greater than 2 mm or very thin layers. Until recently, little has been known about dentally-relevant thicknesses of 1-2 mm - and the results have been surprising and are continuing to develop. Still, at least one fundamental question remains, that could be addressed using informatics techniques: where along the spectrum of flat, polished material to 10-year clinical in-vivo study can we test to accurately predict clinical performance of all-ceramic crowns and bridges? Considerations with respect to strength, or rather the brittleness, of ceramic have for decades undermined the trust in the clinical durability of all-ceramic restorations. This doubt is fed by clinically high failure rates, partly caused by handling mistakes to which ceramic is sensitive, but in some cases caused by a too low intrinsic long-term strength. Metalfree, full-ceramic    restorations, in particular in higher stressed structures, have experienced many ups and downs. However, computerized dentistry has paved the way for a new generation dental ceramic with an unprecedented high strength and durability, derived from developments in nano-ceramic technologies in the last decades. This so-called yttrium-stabilized zirconia gets its strength from a transformation toughening phenomenon also known from the hardening of steel and opens the way towards a completely metalfree restorative and prosthetic dentistry. The last decade the research group for Computerized Dentistry of the Academic Centre for Dentistry Amsterdam has been working in cooperation with industry on the interaction of CAD/CAM technology with new materials applications. Nanostructure of BioZyram Y-TZP
BioZyram